Screening for microsatellite instability target genes in colorectal cancers
نویسندگان
چکیده
منابع مشابه
Screening for microsatellite instability target genes in colorectal cancers.
BACKGROUND Defects in the DNA repair system lead to genetic instability because replication errors are not corrected. This type of genetic instability is a key event in the malignant progression of HNPCC and a subset of sporadic colon cancers and mutation rates are particularly high at short repetitive sequences. Somatic deletions of coding mononucleotide repeats have been detected, for example...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2002
ISSN: 1468-6244
DOI: 10.1136/jmg.39.11.785